HIPPOCOR® Omega–3,6,9 fatty acids from sea buckthorn

HIPPOCOR® Omega–3,6,9 fatty acids from sea buckthorn seeds
FOOD SUPPLEMENT
Registration number within the Food Supplements Register of Latvia: 13869

Sea buckthorn promotes the health of the human cardiovascular system and the functioning of the body’s immune system.

Various natural treasures are concentrated in the sea buckthorn.
One capsule of the HIPPOCOR® corresponds to about 50 grams of fresh sea buckthorn berries.
Sea buckthorn seed lipid extract contains up to 90% unsaturated fatty acids, of which 75% are polyunsaturated fatty acids (linoleic acid and alpha-linolenic acid) and 15% are monounsaturated fatty acids (oleic acid, main ingredient of the olive oil). In addition, sea buckthorn seed lipid extract also contains phytosterols, the most abundant to be beta-sitosterol.

Sea buckthorn seed lipid extract is produced using an innovative, sustainable and environmentally friendly technology – supercritical fluid extraction with carbon dioxide (CO₂). The extraction method is gentle and efficient, ensuring that all active nutrients are preserved and concentrated in the final product.

The product dose not contains solvent (CO₂) residues as it is converted back to the gaseous state after extraction.
HIPPOCOR® contains pure sea buckthorn seed lipid fraction, it does not contain inorganic salts, heavy metals, proteins, fiber and food allergens.

Directions for use: Take 2 capsules per day, preferably with a glass of water. Both capsules can be used at the same time. It is recommended to use the product for 30 days.

Warnings: Do not exceed the recommended daily dose. Do not use food supplements as a substitute for a complete and balanced diet. It is recommended for children from 6 years of age. Not recommended for pregnant and breastfeeding women. Keep out of reach of children. Store in a dry, dark place, at a temperature below +25°C.

Ingredients (per daily dose): Sea buckthorn (Hippophae rhamnoides) seed oil* 2000 mg, capsule shell (gelatine – of fish origin, glycerol, water).
* Obtained by supercritical fluid extraction with CO₂.

Does not contain artificial dyes, organic solvents, pesticides, and GMOs.

Active nutrients

Packing: 30 or 60 softgel capsules

Clinical trial of HIPPOCOR®

In 2021, the Research Institute of Cardiology and Regenerative Medicine of the University of Latvia started a clinical trial of the sea buckthorn seed lipid extract product HIPPOCOR® (Omega–3,6,9 fatty acids from sea buckthorn seeds)^1,2 in which patients with increased residual risk of cardiovascular disease are screened and enrolled*.
In addition to standard medical therapy and medications, enrolled patients take 2000 mg (two capsules) of the HIPPOCOR® food supplement. Up to now, in total 80 patients are screened and enrolled.
Currently, 49 patients who had been using HIPPOCOR® for three months are included in the trial.
Out of 49 patients, 46 patients have completed a three-month follow-up, in which it has been concluded that the product is safe for use (no adverse side effects were observed).
In addition, it has been observed that after 3 months of HIPPOCOR® use there is a tendency of improved blood pressure and glucose level. Furthermore, according to the currently available data, it can be concluded that the metabolism normalizes when HIPPOCOR® is used. Clinical trial of HIPPOCOR® continues, and it is planned to include more than 100 patients.

* Residual risk is the risk of macrovascular events and microvascular complications that persists in the majority of patients despite standard care, even achieving target low-density lipoprotein cholesterol levels and intensively monitoring arterial blood pressure and glucose levels (R3i International Steering Committee).

References:
¹ Sea Buckthorn Seed Oils as a Novel Omega 3 Source for Coronary Heart Disease Patients with Residual Risk, Iveta Mintale et al Medicina (Kaunas) 2022;58(Supplement 1);
² How to Reduce the Residual Cardiovascular Risk: Focus on Phytosterols, Kristaps Erglis et al Medicina (Kaunas) 2022;58 (Supplement 1).

Plant-based Omega fatty acids and plant sterols

Omega–3
Alpha-linolenic acid (Omega–3) is a plant-based polyunsaturated fatty acid that must be consumed with food. It is found in various plants, seeds, flax seeds, hemp seeds and sage, nuts, including sea buckthorn seeds. Epidemiological studies have shown that alpha-linolenic acid is an essential nutrient that can helps reduce the risk of cardiovascular disease.¹
The Lyon Diet Heart Study concluded that patients following Mediterranean dietary habits had a 50–70% reduction in the risk of recurrent cardiovascular disease over a four-year follow-up period.²
Moreover, in a GISSI (Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto miocardico) study, it was observed that following the dietary habits of the Mediterranean diet and additionally using 1 gram of Omega–3 fatty acids per day, a 30% reduction in mortality from cardiovascular diseases was observed and the risk of sudden death from cardiovascular diseases was reduced by 45%.²

Omega–6
Linoleic acid (Omega–6) is an essential polyunsaturated fatty acid that is found in various plants, sesame, hemp, sea buckthorn seeds, as well as various nuts. Linoleic acid is necessary for the normal growth and development of the body.³ Linoleic acid is a precursor for the synthesis of arachidonic acid in the body, which is an important fatty acid for ensuring the functioning of the nervous system, hormone synthesis, and other physiological processes.⁴ Omega–6 fatty acids are necessary for the normal course of inflammation reduction.

Omega–9
Oleic acid (Omega–9) is a monounsaturated fatty acid, which is the main (up to 79%) component of olive oil.⁵ Epidemiological studies have shown that consuming monounsaturated fatty acids, especially olive oil, which is rich in oleic acid, reduces the risk of cardiovascular diseases.⁶ Sea buckthorn seed oil also is a source of oleic acid.

Plant sterols (beta-sitosterol)
Plant sterols, including beta-sitosterol, are found in plant products, mostly in nuts and seeds. The molecular structure of plant sterols is very similar to cholesterol, so when they enter the intestinal tract, they compete with cholesterol for absorption into the blood. Thus, consuming products with plant sterols, including sea buckthorn, may reduce your dietary cholesterol.^7,8

References:
¹ Alpha-linolenic acid and coronary heart disease, M.de Lorgeril et al Nutrition, Metabolism and Cardiovascular Diseases, Volume 14, Issue 3, June 2004, Pages 162-169
² The Mediterranean-style diet for the prevention of cardiovascular diseases Michel de Lorgeril et al Public Health Nutr. 2006 Feb;9(1A):118-23. doi: 10.1079/phn2005933.
³ Hansen, A. E., Haggard, M. E., Boelsche, A. N., Adam, D. J. & Wiese, H. F. Essential fatty acids in infant nutrition. III. Clinical manifestations of linoleic acid deficiency. J. Nutr. 66, 565–576 (1958).
⁴ Brenna, J. T. Arachidonic acid needed in infant formula when docosahexaenoic acid is present. Nutr. Rev. 74, 329–336 (2016).
⁵ The Main Component of Olive Oil on Postprandial Metabolic Processes, SergioLopez et al Olives and Olive Oil in Health and Disease Prevention.
⁶ Bioactive Compounds and Quality of Extra Virgin Olive Oil Cecilia Jimenez-Lopez et al Foods. 2020 Aug; 9(8): 1014.
⁷ Ras RT, Hiemstra H, Lin Y, et al. Consumption of plant sterol-enriched foods and effects on plasma plant sterol concentrations—a meta-analysis of randomized controlled studies. Atherosclerosis. 2013;230:336–346.
⁸ Ferguson JJ, Stojanovski E, MacDonald-Wicks L, et al. Fat type in phytosterol products influence their cholesterol-lowering potential: a systematic review and meta-analysis of RCTs. Prog Lipid Res. 2016;64:16–29.